A transdermal system is the application of active drugs via a patch, which enables more effective and more tolerable absorption (incorporation of the therapeutic active substance into the bloodstream).

Therapeutic systems release the active ingredient particularly slowly and in a controlled manner over a long time window. The active ingredients diffuse through the skin and enter the bloodstream directly via blood vessels close to the skin without passing through the gastrointestinal tract or the liver.

There are various systems for releasing an active ingredient from the patch into the skin, which can be divided into the four areas passive diffusion, energy-driven diffusion, mechanical perforation and energy-driven perforation. Transdermal patches with an active ingredient matrix (matrix patch) allow passive diffusion and occupy a dominant position in the market for transdermal systems.

The main therapeutic advantages of transdermal systems over other dosage forms are in particular:

  • Decreased Application Frequency
  • Constant active ingredient levels
  • Reduced Adverse Effects
  • Improved Drug Intake Compliance
  • Increased bioavailability
  • Improved pharmacokinetics


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